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Phenmetrazine and this analogue acts as a releasing agent of norepinephrine and dopamine with EC50 values of 50.4 ± 5.4 nM and 131 ± 11 nM, respectively. It has negligible efficacy as a releaser of serotonin. 3-methyl-2-(p-tolyl)morpholine is a structural analog of Phenmetrazine in which the aromatic system has been substituted in the 4th position with a methyl group. The physiological and toxicological properties of this compound have not been studied.
3-methyl-2-(p-tolyl)morpholine may be utilised by researchers who wish to use it as a reference sample for their GC/MS, FTIR or NMR analysis catalogues..
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For long term storage, we suggest that 3-methyl-2-(p-tolyl)morpholine be stored at -20°C. It should be stable for at least two years.
3-methyl-2-(p-tolyl)morpholine is supplied as a white crystalline solid. 3-methyl-2-(p-tolyl)morpholine is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of 3-methyl-2-(p-tolyl)morpholine in ethanol and DMF is approximately 10 mg/ml and approximately 20 mg/ml in DMSO.
Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing biological experiments. Ensure that the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects at low concentrations.
Organic solvent-free aqueous solutions of 3-methyl-2-(p-tolyl)morpholine (hydrochloride) can be prepared by directly dissolving the crystalline solid in aqueous buffers. The solubility of 3-methyl-2-(p-tolyl)morpholine (hydrochloride) in PBS, pH 6.2, is approximately 9 mg/ml. We do not recommend storing the aqueous solution for more than one day.
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